Table 3.

Comparison of idiopeptide recognition by splenic effector cells from BALB/c and NZB/W F1 mice using peptide-pulsed and ⁵¹Cr-labelled P815 target cells

	% Target lysis (E:T =100:1)
Peptide used to pulse P815 target cells	BALB/c splenocyte effectors*	NZB/W F1 splenocyte effectors*
VK2-9	10·00 ± 2·64	ND†
VK8-9	16·33 ± 1·15	9·00 ± 7·0
VK9-9	13·00 ± 3·60	17·67 ± 4·61
VK41-9 (FR3)	6·33 ± 4·04	14·33 ± 1·15
VK41-9 (CDR1)	9·00 ± 7·0	18·33 ± 3·05

^*Naïve splenocytes were stimulated in vitro with each peptide for 5 days as described in the Materials and methods.

^†ND, not detected.

CDR, complementarity-determining region; E : T, effector : target; FR, framework region.