Table 2.
Amyloid deposition in C1q knockout mice
| Amyloid deposition | ||||
|---|---|---|---|---|
| Liver | Spleen | |||
| Genotype | 125I-SAP retained* | Amyloid score† | 125I-SAP retained* | Amyloid score† |
| Wild type (day 2) n = 17 | 2·8 (1·7) | 1 (0–1) | 0·6 (0·5) | 3 (2–4) |
| C1q knockout (day 2) n = 15 | 4·4 (2·4) P = 0·5209 | 0 (0–2) P = 0·5711 | 0·7 (0·5) P = 0·8208 | 3 (0–4) P = 0·5384 |
| Wild type (day 3) n = 12 | 10·3 (5·2) | 1 (0–3) | 2·8 (1·0) | 4 (3–4) |
| C1q knockout (day 3) n = 13 | 6·9 (5·6) P = 0·4966 | 1 (0–3) P = 0·204 | 1·1 (0·9) P = 0·0167 | 2 (0–4) P = 0·08853 |
All mice received AEF and AgNO3 on day 0 as described in Methods.
*
Mean (SD),% injected dose of 125I-labelled human SAP retained in organs at death on day 2 or 3, after intravenous tracer injection on day 1 or 2, respectively.
†
Median (range), histological grade of congophilic amyloid deposits assessed as in Methods.
P-values are for Wilcoxon rank sum (Mann–Whitney) tests between C1q knockout and corresponding wild type control groups.