Table 1.
Ezrin/radixin/moesin (ERM)-binding partners in leucocytes
| Binding partner | Cell type | ERM? | Possible role of interaction | Reference |
|---|---|---|---|---|
| Integral membrane proteins | ||||
| ″ICAM-1 | T cells | M, E | Uropod localization | 115 |
| ″ICAM-2 | Thymoma | E | Susceptibility to cytotoxic NK cell killing | 38,67,105 |
| ″ICAM-3 | T cells | M | Polarization | 68–71 |
| ″CD43 | T cells | M, E | Immune synapse formation | 67,100,102,103 |
| ″CD44 | T cells | M, E | Uropod localization | 67,70,71 |
| ″CD95 (Fas) | T cells | E | Uropod localization Apoptosis | 72,73 |
| ″PSGL-1 | K562 (myeloid) | M | Rolling Uropod localization | 84,85 |
| ″L-selectin | Lymphocytes | M, E | Microvillar positioning PMA-induced shedding | 85,86, and personal communication |
| ″P-glycoprotein | CEM-VBL100 | E, R, M | Uropod localization Multi-drug resistance | 116 |
| Cytosolic proteins | ||||
| ″EBP-50 | T cells | M, E | Negative regulation of IS formation | 66 |
| ″Calpain | T cells | M | Specific cleavage of moesin | 40 |
| ″P40phox and P47phox | U937 cells | M | Phagosome formation? | 114 |
| ″P56Lck | Jurkat T cells | E | Tyrosine phosphorylates ezrin on Y145 | 104 |
| ″Syk | K562 cells | M | PSGL-1 signalling | 75 |
| ″PI3-kinase | LLC and lymphocytes | E | Apoptotic survival | 107,108 |
In the table above, the known binding partners for ERM proteins in leucocytes are listed, together with the cell type in which the interaction was identified, the ERM proteins with which they are known to interact (E = ezrin, R = radixin M = moesin), and the role of the interaction in leucocyte responses.EBP-50, ERM-binding phospho-protein of 50 000 molecular weight; ICAM-1, intercellular adhesion molecule type 1; ICAM-2, intercellular adhesion molecule type 2; IS, immunological synapse; NK, natural killer; PI3-kinase, phosphatidylinositide 3-kinase; PMA, phorbol 12-myristate 13-acetate; PSGL, P-selectin glycoprotein-ligand-1.