Table 2.
Response to immunization with apoptotic cells in SAP–/– and wild-type SAP+/+ C57BL/6 mice
| Positive,n (%) | ||||||
|---|---|---|---|---|---|---|
| n | ANA | Anti-dsDNA | Anti-chromatin | Anti-ssDNA | Glomerulonephritis | |
| Female | ||||||
| ″wild type | 20 | 1 (5) | 4 (20) | 9 (45) | 5 (25) | 0 (0) |
| ″SAP–/– | 26 | 18 (69) | 9 (35) | 20 (77) | 16 (62) | 9 (36) |
| P<0·0001 | P = 0·33 | P<0·04 | P<0·02 | P<0·003 | ||
| Male | ||||||
| ″wild type | 10 | 0 (0) | 2 (20) | 6 (60) | 2 (20) | 0 (0) |
| ″SAP–/– | 9 | 3 (33) | 4 (44) | 4 (44) | 2 (22) | 0 (0) |
| P = 0·09 | P = 0·35 | P = 0·36 | P = 1·0 | P = 1·0 | ||
P-values obtained by χ2 test or Fisher's exact test as appropriate.
Mice received 107 apoptotic syngeneic thymocytes in a single intravenous injection each week for 4 weeks. Autoantibodies were estimated on day 28 and glomerulonephritis on day 56.