Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
The hypothesis of reduced immune regulation as an explanation for the increased prevalence of allergy as a consequence of improved hygiene. The reduced microbial burden during childhood results in reduced stimulation of Treg cells, with consequent implementation of both Th1 and Th2 responses which are responsible for the increased prevalence of both autoimmune and allergic disorders, respectively.
