Figure 1.

Allergic rhinitis model. BALB/c mice (four per group) were s.c. sensitized with OVA and alum on three occasions spaced 1 week apart. One week after the last sensitization (Day 28), mice received a series of seven daily i.n. OVA challenges. Additional subsets of mice received ISS-ODN or C-ODN via the i.d. or i.n. routes, or i.p. DXM, one day prior to initiating i.n. OVA challenges (Day 27). Mice were killed for analyses 15 min or 24 hr after the last i.n. OVA challenge.