Table 2.

IL-6 secretion induced by CpG and non-CpG ODN in murine TLR9^–/– splenocytes

		IL-6 secretion (pg/ml)
ODN	Conc. (μg/ml)	TLR9+ / +	TLR9–/–
None		98·3 ± 4·9	54·4 ± 36·4
2006	1	923·8 ± 20·2	79·5 ± 73·9
	3	1977·6 ± 191·5	80·8 ± 50·4
	10	3449·2 ± 225·7	113·1 ± 30
2137	1	190 ± 5·6	80 ± 54·1
	3	258·3 ± 17·6	97·1 ± 39·9
	10	335 ± 21·7	95·4 ± 25·5

TLR9^+/+ or TLR9^–/– BALB/c splenocytes were cultured with the indicated ODN for 48 hr. Supernatants were harvested and IL-6 was measured by ELISA. The mean ± SD of two independent ELISA of one out of two experiments is shown.