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Survival of IFN-γ−/− and IFN-γR−/− mice inoculated with B16 melanoma cells. Mice were intravenously inoculated with 1 × 105 B16 melanoma cells. Closed circle: wild-type mice, n = 15; open circle: IFN-γ−/− mice, n = 21; open square: IFN-γR−/−, n = 8. *P < 0·05: IFN-γR−/− versus wild-type, **P < 0·01: IFN-γ−/− versus wild-type mice.
