Table 1. Role of antibody-dependent cellular cytotoxicity (ADCC) in chlamydial control.
| Cultures* | % Cytotoxicity ″(± SEM) |
|---|---|
| TM3 cells+MoPn | 8·20 (2·1) |
| TM3 cells+MoPn+Anti-MoPn | 5·30 (0·5) |
| TM3 cells+MoPn+Anti-TB | 4·22 (2·1) |
| TM3 cells+MoPn+PEMs | 22·62 (3·3) |
| TM3 cells+MoPn+Anti-MoPn+PEMs | 79·66 (2·3) |
| TM3 cells+MoPn+Anti-TB+PEMs | 19·80 (2·6) |
| TM3 cells+MoPn+KO-PEMs | 15·80 (5·2) |
| TM3 cells+MoPn+Anti-MoPn+KO-PEMs | 18·60 (6·3) |
| TM3 cells+MoPn+Anti-TB + KO-PEMs | 20·40 (4·1) |
*
% Cytotoxicity in control cultures containing TM3 cells+antibodies to Mycobacterium tuberculosis (anti-TB), TM3 cells+antibodies to Chlamydia muridarum (anti-MoPn; the C. trachomatis agent of mouse pneumonitis), TM3 cells+peritoneal exudate macrophages from wild-type mice (PEMs), TM3 cells+anti-MoPn+PEMs, and TM3 cells+anti-TB+PEMs were 0·0, 0·0, 2·10 (1·5), 3·15 (1·6), and 2·52 (1·4), respectively. Percentage cytotoxicity in equivalent control cultures containing PEM from FcRKO mice (KO-PEM) was less than 3·0%. A total of 10 4 TM3 cells were plated per well
SEM, standard error of the mean.