Table 1. CXC, C and CX3C chemokines and chemokine receptors superfamily.
| Systematic name | Human ligand | Mouse ligand | Chemokine receptors |
|---|---|---|---|
| CXC family | |||
| CXCL1 | GRO-α/MGSA-α | GRO/KC | CXCR2 |
| CXCL2 | GRO-β/MGS-β/MIP-2α | GRO/KC | CXCR2 |
| CXCL3 | GRO-γ/MGSA-γ/MIP-2β | GRO/KC | CXCR2 |
| CXCL4 | PF4 | PF4 | Unknown |
| CXCL5 | ENA-78 | LIX | CXCR1; CXCR2 |
| CXCL6 | GCP-2 | Ckα-3 | CXCR1 |
| CXCL7 | NAP-2 | Unknown | CXCR2 |
| CXCL8 | IL-8 | Unknown | CXCR1; CXCR2 |
| CXCL9 | Mig | Mig | CXCR3 |
| CXCL10 | IP-10 | IP-10 | CXCR3 |
| CXCL11 | I-TAC/H174 | Unknown | CXCR3 |
| CXCL12 | SDF-1α/β/PBSF | SDF-1 | CXCR4 |
| CXCL13 | BLC/BCA-1 | BLC/BCA-1 | CXCR5 |
| CXCL14 | BRAK/Bolekine | BRAK/BMAC | Unknown |
| CXCL15 | Unknown | Lungkine | Unknown |
| C family | |||
| XCL1 | Lymphotactin/SCM-1α | Lymphotactin | XCR1 |
| XCL2 | SCM-1β/ATAC | Unknown | XCR2 |
| CX3C family | |||
| CX3CL1 | Fractalkine | Fractalkine/Neurotactin | CX3CR1 |
ATAC, activation-induced, T cell-derived, and chemokine-related; BCA-1, B-cell-attracting chemokine 1; BLC, B-lymphocyte chemoattractant; BMAC, B-cell and monocyte-activating chemokine; BRAK, breast and kidney derived chemokine; CXCL, CXC chemokine ligand; ENA-78, epithelial-cell-derived neutrophil-activating peptide 78; GCP-2, granulocyte chemoattractant protein 2; GRO, growth-related oncogene; IL-8, interleukin 8; IP-10, interferon-inducible protein 10; I-TAC, interferon-inducible T-cell alpha chemoattractant; LIX, lipopolysaccharide-induced CXC chemokine; MGSA, melanocyte growth stimulatory activity; Mig, monokine induced by interferon-γ; MIP, macrophage inflammatory protein; NAP-2, neutrophil activating peptide 2; PF4, platelet factor 4; SCM-1, single C motif-1; SDF-1, stromal-cell-derived factor 1. For recent updates on the nomenclature, see the review in this issue by Watson73.