Table 1. Studies demonstrating association between tumour-expressed FasL and apoptosis and loss of TILs in situ in human cancers.
Tumour type | Ref. | Cases studied (n) | FasL's association with apoptosis and loss of TILs |
---|---|---|---|
Ovarian | 10 | 132 | Decreased CD3+ and CD8+ TILs |
Colon | 13 | 41 | Increased apoptosis of TILs (P < 0·01); decreased TIL numbers |
Oesophageal | 14 | 106 | Decreased CD8+ TILs (P = 0·0011); increased apoptosis of TILs″(n = 6, P < 0·05);9 decreased TIL numbers (n = 6, P < 0·05)9 |
Mycosis fungoides lymphoma | 12 | 21 | Increased apoptosis of CD8+ TILs; decreased CD8+ TIL numbers (P < 0·02) |
Gastric cancer | 11 | 100 | Increased apoptosis of TILs (P = 0·057) |
Angiosarcoma | 15 | 40 | Decreased CD3+ and CD8+ TILs (P ≤ = 0·004) |