Table 1. PEL-CTL is resistant to Jo2 but sensitive to FasL expressed on cell surface.
| % 51Cr release at E:T | |||||
|---|---|---|---|---|---|
| PEL-CTL | Pre-incubation with | Target | 10:1 | 5:1 | SR |
| BALB/c anti-BW | – | BW | 56·1 | 38·2 | 8·3 |
| BALB/c anti-BW | Jo2 (1 µg/ml) | BW | 53·2 | 34·9 | 8·3 |
| BALB/c anti-BW | P0 anti-LF+ PEL (1:2) | BW | 28·0 | 18·4 | 8·3 |
SR, spontaneous release.
BALB/c anti-BW PEL-CTL (d anti-k), were preincubated with Jo2, or with cognate P0 anti-LF+ PEL (b anti-d) for 16 hr (at a 1:2 ratio of BALB/c PEL to P0 anti-LF+ PEL), before adding
51
Cr-labelled indicator targets (3 × 104 cells/well). Lysis was assessed after 3 hr.