Table 2. Cytokine patterns and immunophenotyping of the individual granulomas for the seven patients.
| Patient | Total no. granulomas | Caseous necrosis | IFN-γ protein | TNF-α protein | IL-4 protein | IL-12p40 mRNA | CD8+ | CD8+ IL-12p40+ | CD4+ |
|---|---|---|---|---|---|---|---|---|---|
| B1 | 10* | 2 (20)† | 9 (90) | 10 (100) | 0 (0) | 9 (90) | 5 (50) | 1 (10) | 10 (100) |
| B2 | 40 | 9 (23) | 37 (93) | 30 (75) | 0 (0) | 29 (73) | 23 (58) | 5 (13) | 37 (93) |
| B3 | 12 | 4 (33) | 4 (33) | 11 (92) | 4 (33) | 9 (75) | 6 (50) | 1 (8) | 11 (92) |
| B4 | 15 | 8 (53) | 10 (67) | 8 (53) | 6 (40) | 11 (73) | 7 (48) | 2 (13) | 13 (87) |
| B5 | 23 | 9 (39) | 17 (74) | 15 (65) | 5 (22) | 17 (74) | 11 (46) | 3 (13) | 22 (96) |
| B6 | 29 | 7 (24) | 26 (90) | 21 (72) | 0 (0) | 25 (86) | 14 (49) | 3 (10) | 25 (86) |
| B7 | 12 | 4 (33) | 9 (75) | 4 (33) | 5 (42) | 8 (67) | 6 (50) | 2 (16) | 11 (92) |
All values are number with % of total in parenthesis.
*
The absolute number of granulomas is given.
†
The percentage of granulomas giving a positive result for a particular parameter is given.