Table 1.
Properties of selected mammalian mast cell granule serine proteinases
| Species | Proteinase | Specificity | SWISS-PROT | MW* | PI* | Reference |
|---|---|---|---|---|---|---|
| Man | Tryptase-αI | T | P15157 | 27701 | 6·20 | 20 |
| Tryptase-βI | T | Q15661 | 27444 | 6·30 | 21,22 | |
| Tryptase-βII | T | P20231 | 27458 | 6·46 | 22,23 | |
| Tryptase-γI | T | Q9NRR2 | 30230 | 6·24 | 24,25 | |
| Chymase | Cα | P23946 | 25030 | 9·60 | 26,27 | |
| Cathepsin G | T/C | P08311 | 25441 (Ile21–Ser244) | 11·51 (Ile21–Ser244) | 28 | |
| Mouse | MCP-1 | C | P11034 | 24956 | 8·46 | 29 |
| MCP-4 | C | P21812 | 25146 | 9·67 | 30 | |
| MCP-5 | Cα | P21844 | 25343 | 9·51 | 31,32 | |
| MCP-6 | T | P21845 | 27483 | 6·21 | 33 | |
| MCP-7 | T | Q02844 | 27411 | 5·69 | 34 | |
| Transmembrane tryptase | T | Q9QUL7 | 29788 | 5·88 | 25 | |
| Rat | MCP-1 | C | P09650 | 25191 (Ile21–Asp247) | 9·77 (Ile21–Asp247) | 35 |
| MCP-2 | C | P00770 | 25044 | 8·70 | 36,37 | |
| MCP-6 | T | P50343 | 27473 | 5·90 | 38 | |
| MCP-7 | T | P27435 | 27432 | 5·89 | 39,40 | |
| Dog | Tryptase | T | P15944 | 27153 | 6·37 | 41 |
| Chymase | Cα | P21842 | 25461 | 9·93 | 42,43 | |
| Sheep | Tryptase-1 | T | Q9XSM1 | 27376 | 5·52 | 9 |
| Tryptase-2 | T | Q9XSM2 | 27494 | 5·68 | 9 | |
| MCP-1 | T/C | P80931 | 24952 | 8·90 | 44 | |
| Cow | Tryptase | T | Q29464 | 27302 | 8·12 | 45 |
| Duodenase† | T/C | P80219 | 25051 | 9·03 | 46 |
*
For theoretical core protein.
†
Detected in bovine intestinal mast cells (A. D. Pemberton & T. S. Zamolodchikova, unpublished).
Cα, α-chymase; C, other chymase; MCP, mast cell proteinase; MW, molecular weight; PI, isoelectric point; T, tryptase.