Figure 4.

Cytotoxic T-lymphocyte (CTL) activities, 5 days post-transplantation, of graft-infiltrating cells (GICs) in B6^+/+ hepatic allografts in MRL^+/+ (a) and -lpr (b) recipients, grafted with B6^+/+ donor livers. A short-term 4-hr ⁵¹Cr-release assay was performed to determine the cytotoxicities of whole, CD4-depleted and CD8-depleted GICs against B6^+/+ (Fas⁺) and -lpr (Fas⁻) splenic concanavalin A (Con A) blast cells. Data represent average values from triplicate wells. Similar results were obtained in two other independent experiments.