Table 1. Region showing evidence for linkage to asthma and allergic phenotypes in genome-wide screening.
Locus | Australian4 | CSGA5,6 | Dutch7 | French8 | German9 | Japanese10 | Hutterites11 |
---|---|---|---|---|---|---|---|
1p | – | Asthma (Hispanic)6 | – | Asthma | Eosinophils | – | Skin test |
Total IgE | Asthma | ||||||
Specific IgE | |||||||
2p | – | – | – | – | Asthma | – | – |
BHR | |||||||
Total IgE | |||||||
RAST | |||||||
Specific IgE | |||||||
2q | – | Asthma (Hispanic)5 | – | – | Total IgE | – | Skin test |
3p | – | – | BHR | – | – | – | Asthma |
Skin test | |||||||
4q | BHR | – | – | – | RAST | Mite-sensitive atopic asthma | – |
5p | – | Asthma (African American)5 | – | – | Specific IgE | – | BHR |
5q | – | – | BHR | – | – | Mite-sensitive atopic asthma | Asthma |
Asthma symptoms | |||||||
6p | Eosinophils | Asthma (Caucasian)6 | – | – | Asthma | Mite-sensitive atopic asthma | – |
Atopy | RAST | ||||||
Total IgE | |||||||
Eosinophils | |||||||
7p | BHR | – | – | – | RAST | – | – |
Total IgE | |||||||
8p | – | – | – | – | – | – | Asthma |
9p | – | – | – | – | BHR | – | Asthma symptoms |
9q | – | – | – | – | Asthma | – | – |
10q | – | – | Total IgE | – | Specific IgE | – | – |
11p | – | Asthma (Caucasian)5 | – | Total IgE | – | – | Skin test |
11q | Total IgE | Asthma (African ″American)6 | – | Total IgE | Eosinophils | – | – |
Skin test | |||||||
12q | – | Asthma (Caucasian)5 | Total IgE | Eosinophils | – | Mite-sensitive atopic asthma | Asthma |
Skin test | |||||||
13q | Atopy | Asthma (Caucasian)5 | – | Eosinophils | – | Mite-sensitive atopic asthma | Asthma symptoms |
14q | – | Asthma (Caucasian)5 | – | – | – | – | Asthma |
15q | – | – | – | – | Total IgE | – | – |
Specific IgE | |||||||
16q | Total IgE | – | – | – | – | – | Skin test |
17p | – | Asthma (African ″American)5 | – | – | – | – | – |
17q | – | – | Total IgE | Asthma | – | – | – |
Skin test | |||||||
18p | – | – | – | – | – | – | Asthma symptoms |
19q | – | Asthma (Caucasian)5 | – | – | – | – | BHR |
20p | – | – | – | – | – | – | Skin test |
21q | – | Asthma (Caucasian)5 | – | – | – | – | – |
Xq | – | – | – | – | Total IgE | – | – |
Eosinophils |
Only values P<0·01 are shown.