Table 1. Summary of the data on the different mutant mice.
Mouse strain | Growth of M. avium | Granulomas | Necrosis |
---|---|---|---|
C57BL/6 (B6) | Well structured | Present | |
B6-Nu/Cφ | Well structured | Present | |
B6-Nu/Nu | Increased* | Poorly structured† | Absent |
B6-CD4−/− | Increased* | Poorly structured† | Absent |
B6-CD8α−/− | Similar to control* | Well structured | Present |
B6-TCRδ−/− | Similar to control* | Well structured | Present |
B6-CD54−/− | Similar to control* | Well structured | Reduced‡ |
B6-CD40−/− | Similar to control* | Poorly structured | Absent |
B6-IL12p40−/− | Similar to control* | Incipient† | Absent |
B6-IFNγ−/− | Increased* | Incipient | Absent |
B6-TNFRp55+/− | Similar to control* | Well structured | Present |
B6-IL6−/− | Similar to control* | Well structured | Reduced‡ |
B6-IL10−/− | Reduced* | Well structured | Reduced§ |
B6-perforin−/− | Similar to control* | Well structured | Present |
B6-iNOS−/− | Reduced* | Well structured | Present¶ |
B6+/bcl2 | Similar to control* | Well structured | Present |
The Student's t-test was used to analyse the statistical significance of the differences. Only statistically significant increases or decreases in viable counts are reported in this table.
Incipient granulomas were mostly formed by few heavily infected macrophages with little or no lymphoid involvement. Poorly structured granulomas had less lymphoid cuffing than granulomas of control mice.
Reduction in necrosis was observed both as a reduction in the number of lesions per organ and the occurrence of a percentage of the mice which totally lacked necrotic lesions.
The lesions showed necrosis later than control mice.
The lesions were fewer in number but bigger in size.