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. 2003 Jan;108(1):50–54. doi: 10.1046/j.1365-2567.2003.01547.x

Figure 1.

Figure 1

C57BL/6 IL-12 p40-deficient mice develop a more severe mTg and LPS induced thyroiditis in comparison to the wild type C57BL/6. 5 C57BL/6 IL-12 p40 deficient mice and 5 C57BL/6 mice were immunized with mTg and LPS, 28 days after the first immunization sera and thyroids were collected for analysis. (a) Serum (diluted 1/50) antibody response against mTg, total immunoglobulins (P < 0·0006), IgG2a (P < 0·0074) and IgG2b (P < 0·0003) are significantly increased in the C57BL/6 IL-12 p40-deficient mice, there is no significant difference in the anti mTg IgG1 isotype (P < 0·0259). (b) Histological score of thyroid lesion. Thyroids from C57BL/6 IL-12 p40 deficient mice are more infiltrated than C57BL/6 mice thyroids.