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. 2003 Jan;108(1):50–54. doi: 10.1046/j.1365-2567.2003.01547.x

Figure 3.

Figure 3

Differences in the cytokine secretion profiles of wild-type and IL-12 p40 deficient mice. PEC from thioglycollate-treated mice were stimulated in vitro with LPS (5 µg/ml), supernatants were sampled every 4 hr for cytokine concentrations. Unstimulated cells did not produce detectable amounts of cytokines (not shown). (a) PEC from C57BL/6 IL-12 p40-deficient mice did not secrete IL-12; (b) PEC from C57BL/6 IL-12 p40-deficient mice secrete more TNF-α (P < 0·0005); (c) less IL-10 (P < 0·001) than C57BL/6 mice; and (d) similar levels of NO.