Table 4.
C57BL/6 mice challenged with virulent M. bovis 14 weeks after first vaccination
| Vaccine group | Log 10 mean viable bacteria (lung) ± SE | Log 10 protection (lungs)* | Log 10 mean viable bacteria (spleen) ± SE | Log 10 protection (spleen)* |
|---|---|---|---|---|
| PBS/PBS/PBS | 4·76 (±0·07) | 0†‡ | 3·97 (±0·14) | 0† |
| DNA/DNA/DNA | 4·28 (±0·68) | 0·49‡ | 3·75 (±0·17) | 0·22† |
| Plasmid/plasmid/plasmid | 5·34 (±0·13) | −0·58† | 3·92 (±0·22) | 0·05† |
| DNA/DNA/BCG | 4·46 (±0·26) | 0·30†‡ | 2·86 (±0·14) | 1·11‡ |
| DNA/DNA/WAg520 | 4·49 (±0·24) | 0·27†‡ | 2·21 (±0·37) | 1·76‡ |
| Plasmid/plasmid/BCG | 4·32 (±0·14) | 0·44‡ | 2·57 (±0·19) | 1·47‡ |
| Plasmid/plasmid/WAg520 | 4·14 (±0·30) | 0·63‡ | 2·57 (±0·27) | 1·40‡ |
*
Groups with same symbol are not significantly different from each other (P > 0·05).