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Codon switch by A-to-I RNA editing. Editing in the coding region of mRNA could switch the codon identity. The arrows indicate <0·1% codon switch in normal conditions and 5% during acute inflammation. If editing occurs at the first or second codon positions, it switches the encoded amino acids. Editing at the third codon position or outside of the coding region of inosine-containing mRNA is termed ‘silent’ editing.
