Table 1.
Expression of CD28, CD45RA and CD45RO as well as the ratio of interferon-γ (IFN-γ)+/interleukin-4 (IL-4)+ T cells (CLA+ and CLA−) after stimulation with phytohaemagglutinin (PHA) and staphylococcal enterotoxin B (SEB)
| CLA+ | CLA− | |||
|---|---|---|---|---|
| <40 years | >60 years | <40 years | >60 years | |
| CD28+ | ||||
| SEB | 5·77 ± 1·60 | 3·73 ± 0·54 | 67·26 ± 4·95 | 44·72 ± 14·98* |
| PHA | 6·65 ± 1·72 | 5·41 ± 2·50 | 56·72 ± 6·15 | 36·92 ± 14·60* |
| CD45RA+ | ||||
| SEB | 5·85 ± 1·64 | 6·55 ± 4·52 | 53·39 ± 6·03 | 34·99 ± 6·59† |
| PHA | 5·25 ± 2·35 | 5·36 ± 3·23 | 46·13 ± 4·17 | 31·99 ± 9·94 |
| CD45RO | ||||
| SEB | 6·61 ± 0·76 | 6·85 ± 3·38 | 38·12 ± 6·10 | 40·48 ± 8·32 |
| PHA | 4·16 ± 1·76 | 3·45 ± 2·10 | 34·00 ± 8·20 | 43·15 ± 9·91 |
| IFN-γ+/IL-4+ | ||||
| SEB | 2·28 ± 1·15 | 2·89 ± 1·92 | 6·38 ± 3·62 | 5·47 ± 2·25 |
| PHA | 2·61 ± 1·61 | 4·38 ± 2·83 | 2·69 ± 0·93 | 7·72 ± 3·95* |
CTA, cutaneous lymphocyte antigen.
*
P < 0·04 compared with CLA− T cells from young individuals.
†
P < 0·01 compared with CLA− T cells from young individuals.