Figure 1.

Bronchial responsiveness to acetylcholine in sensitized rats exposed repeatedly to saline or ovalbumin: There was a greater than half-log order increase in the mean -log concentration of acetylcholine required to increase baseline resistance by 200% (PC₂₀₀ value) in rats repeatedly exposed to allergen compared with the saline-exposed group (***P <0·001). Neither cyclosporin A (CsA) nor SAR943 attenuated the -log PC₂₀₀ values compared with the vehicle-treated rats. Data are expressed as mean-log PC₂₀₀ values, with bars representing 95% confidence intervals.