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. 2003 Jul;109(3):461–467. doi: 10.1046/j.1365-2567.2003.01672.x

Figure 4.

Figure 4

Effects of cyclosporin A (CsA) and SAR943 on eosinophil major basic protein (MBP)-positive eosinophil recruitment to the airways (a) and parenchyma (b) following repeated allergen challenge. (a) There was a significant increase in the number of MBP-positive eosinophils around the airways following repeated allergen exposure of rats compared with repeated saline exposure (***P < 0·001). Neither CsA nor SAR943 attenuated eosinophil recruitment to the airways as compared with the vehicle-treated group. (b) There was also a significant increase in MBP-positive eosinophil recruitment into the parenchyma of repeatedly allergen-exposed, compared with repeatedly saline-exposed, rats (**P < 0·01). Neither CsA nor SAR943 altered eosinophil recruitment compared with vehicle-treated rats. Data are expressed as mean values ± standard error of the mean (SEM).