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. 2003 Jul;109(3):461–467. doi: 10.1046/j.1365-2567.2003.01672.x

Figure 5.

Figure 5

Effects of cyclosporin A (CsA) and SAR943 on CD2+ (a), CD4+ (b) and CD8+ (c) T-cell recruitment to the airways following repeated challenge with allergen. There was a significant increase in the number of (a) CD2+ (**P < 0·01) T cells and (b) CD4+ (*P < 0·05) T cells around the airways following repeated allergen exposure of rats compared with repeated saline exposure. Neither CsA nor SAR943 attenuated the recruitment of CD2+ T cells to the airways as compared with the vehicle-treated group (a). SAR943, but not CsA, attenuated the recruitment of CD4+ T cells to the airways, as compared with the vehicle-treated group (#P < 0·05) (b). Neither CsA nor SAR943 altered CD8+ T-cell recruitment compared with vehicle-treated rats. Data are expressed as mean values ± standard error of the mean (SEM).