Table 3.
Summary of FACS data from peripheral blood
Early responder asthmatics (n = 7) | Dual responder asthmatics (n = 10) | |
---|---|---|
CD34+ | ||
″Pre-allergen | 741 (%77) | 832 (%109) |
″24 hr post-allergen | 776 (%108) | 1068 (%89) |
CD34+IL5Rα+ | ||
″Pre-allergen | 7 (%3) | 25 (%8)* |
″24 hr post-allergen | 15 (%6) | 18 (%6) |
CD34+CCR3+ | ||
″Pre-allergen | 6 (%3) | 19 (%2)* |
″24 hr post-allergen | 5 (%2) | 17 (%6) |
Data are presented as cells/106 WBC and expressed as geometric mean and standard error of geometric mean (%SEM). Significantly higher baseline (pre-allergen) levels of CD34+ IL5Rα+ and CD34+CCR3+ cells were detected in the blood of dual responder compared with early responder asthmatics. However, when pre-allergen were compared with 24 hr post-allergen levels, no significant change in numbers of blood CD34+IL5Rα+ and CD34+CCR3+ cells were detected in either group of asthmatics.
P < 0.05 for between group comparisons of baseline levels of progenitor cells.