Table 1.

Effect of IL-18 on expression of adhesion molecules on human monocytes and lymphocytes^*

	Monocytes			Lymphocytes
Molecule	Control	IL-18	P-value†	Control	IL-18	P-value†
ICAM-1	309 ± 68	623 ± 89	P < 0·01	15 ± 3	19 ± 3	NS
CD14	810 ± 60	818 ± 96	NS	15 ± 11	10 ± 5	NS
CD18	570 ± 39	681 ± 10	NS	151 ± 17	156 ± 7	NS
CD11a	451 ± 42	474 ± 46	NS	157 ± 22	175 ± 11	NS
CD11b	563 ± 119	581 ± 41	NS	47 ± 26	48 ± 15	NS
CD11c	395 ± 41	526 ± 33	NS	8 ± 1	14 ± 2	NS
CD29	557 ± 76	543 ± 117	NS	80 ± 15	77 ± 12	NS
CD49d	64 ± 3	115 ± 47	NS	43 ± 4	46 ± 4	NS
CD49e	305 ± 47	287 ± 74	NS	24 ± 2	27 ± 5	NS
ICAM-2	89 ± 13	86 ± 20	NS	51 ± 7	50 ± 7	NS
ICAM-3	272 ± 51	253 ± 59	NS	140 ± 22	135 ± 25	NS
ALCAM	126 ± 10	101 ± 24	NS	13 ± 1	11 ± 1	3NS

^*PBMC were stimulated with IL-18 (1 µg/ml). The expression of the various adhesion molecules was assessed after 24 hr of incubation. Data represent the mean fluorescence ± SEM of four separate experiments.

^†NS, not significant.