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C5a induces IL-10 production in DC correlating to C5aR expression.Stimulation of DC(PGE2) resulted in significantly increased IL-10 production upon either 1 µg/ml or 0·1 µg/ml C5a as determined by ELISA. Immature DC showed only after 1 µg/ml C5a stimulation significant increased IL-10 production, whereas DC(IFN-γ) did not significantly alter their IL-10 production after C5a stimulation. The mean value ± SEM of five different experiments is shown (*, significant difference, P < 0.05).
