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Structural location of AGC conserved features in a prototypic AGC kinase structure. (A) NLT interactions with the N lobe. (B) CLT interactions with the C lobe and interlobe region formed between the αC–β4 loop, β8 strand, and E-helix. (C) CLA interactions with F-helix. Secondary structural elements of the kinase domain and C-tail are colored gray and maroon, respectively.
