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. 2007 Jan 16;104(4):1371–1376. doi: 10.1073/pnas.0607038104

Fig. 3.

Fig. 3.

ISG15−/− mice display increased susceptibility to herpes virus infection. (A and B) ISG15+/+ (open squares) or ISG15−/− (filled squares) mice were infected with HSV-1 by intracranial (i.c.) infection at either 20 pfu i.c. (A) or 2 pfu i.c. (B) and were followed for lethality. (C and D) ISG15+/+ (open squares), ISG15−/− (filled squares), or ISG15+/− (open triangles) mice were infected with HSV-1 by corneal scarification at either 2 × 104 pfu per eye (C) or 2 × 105 pfu per eye (D) and followed for lethality. (E and F) ISG15−/− (filled bars) or ISG15+/+ (open bars) mice were infected with murine γHV68 at a dose of 1 × 106 pfu i.p. At the indicated times postinfection, liver (E) or lungs (F) were isolated and titered by standard plaque assay. ∗, P < 0.01; ∗∗, P < 0.001. The number of mice per group is indicated in parentheses. All experiments were performed in 129OLA/C57BL/6 chimeric mice except for those in (B), which was confirmed in animals backcrossed to C57BL/6 for 10 generations.