Table 1.
Comparison of nucleotide lengths of CDR3 components
| Mutated | Non-mutated | |||||
|---|---|---|---|---|---|---|
| Length | Young | Old | Young | Old | Mutated versus non-mutated† | Young versus old‡ |
| Total CDR3§ | 33.3 (1.5)* | 32.7 (1.4) | 39.4 (1.8) | 41.8 (1.1) | <0.0001 | 0.55 |
| VH6 segment§ | 0.96 (0.11) | 0.80 (0.11) | 1.15 (0.14) | 1.23 (0.08) | 0.0023 | 0.71 |
| D segment¶ | 12.9 (0.9) | 11.7 (0.8) | 14.5 (0.9) | 15.0 (0.5) | 0.0006 | 0.71 |
| JH segment§ | 10.5 (0.8) | 11.6 (0.7) | 14.0 (1.0) | 13.8 (0.6) | 0.0004 | 0.53 |
| P nucleotides¶ | 0.25 (0.18) | 0.25 (0.16) | 0.64 (0.2) | 0.76 (0.11) | 0.0030 | 0.68 |
| N nucleotides¶ | ||||||
| 5′ of D | 6.46 (1.15) | 6.03 (1.07) | 5.88 (1.22) | 6.46 (0.68) | >0.9 | >0.9 |
| 3′ of D | 5.00 (0.84) | 4.62 (0.79) | 5.48 (0.89) | 6.10 (0.50) | 0.14 | 0.81 |
*
Standard errors in parentheses.
†
P-value for the comparison of mean lengths adjusted for age.
‡
P-value for the comparison of mean lengths adjusted for mutation status.
§
The analysis included 52 mutated clones from young people, 56 mutated clones from old people, 33 non-mutated clones from young people, and 94 non-mutated clones from old people.
¶
The analysis of clones with identified D gene segments: 28 mutated clones from young people, 32 mutated clones from old people, 25 non-mutated clones from young people, and 79 non-mutated clones from old people.