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. 2001 Jun;103(2):226–234. doi: 10.1046/j.1365-2567.2001.01222.x

Figure 1.

Figure 1

Effects of DNA on IL-12 production from spleen cells. SRA–/– and WT murine spleen cells were stimulated with various doses of a CpG-containing oligonucleotide (CpG ODN) and E. coli DNA (EC DNA), together with a non-CpG oligonucleotide (control ODN) and calf thymus DNA (CT DNA) as controls. Supernatants were harvested after 24 hr and assayed for IL-12 p40/70 by ELISA. CpG ODN (a) and EC DNA (b) induced increased production of IL-12, while control ODN and CT DNA did not (data not shown). The different strains of mice used as WT mice are indicated. Results are presented as means±SEM.