Table 2.
The effects of anti-IFN-γ treatment and IFN-γ heterozygosity on organ histology of SOCS1−/− mice
| SOCS1genotype | SOCS1+/+/+/− | SOCS1−/− | SOCS1+/+/+/− | SOCS1−/− | SOCS1+/− | SOCS1−/− |
|---|---|---|---|---|---|---|
| IFN-γ genotype | IFN-γ+/+ | IFN-γ+/+ | IFN-γ+/+ | IFN-γ+/+ | IFN-γ+/− | IFN-γ+/− |
| State of health | healthy | sick | healthy | healthy | healthy | healthy |
| Treatment | Anti-IFN-γ Ab | Anti-IFN-γ Ab | Anti-IFN-γ Ab | Anti-IFN-γ Ab | Untreated | Untreated |
| Age (days) | 35–70 | 27–70 | 21 | 21 | 21 | 21 |
| No. of mice analysed | 17–19 | 18–20 | 9 | 6 | 8–9 | 7–9 |
| Lymphoid foci | ||||||
| liver | 5 | 90 | 0 | 0 | 0 | 33 |
| lung | 16 | 75 | 0 | 88 | 0 | 67 |
| salivary gland | 0 | 53 | 0 | 25 | 0 | 78 |
| Liver fatty degeneration | 0 | 0 | 0 | 0 | 0 | 0 |
| Thymus cortex atrophy | 0 | 67 | 0 | 33 | 0 | 57 |
| Muscle infiltration | ||||||
| major | 0 | 70 | 0 | 50 | 0 | 56 |
| minor | 11 | 15 | 0 | 25 | 11 | 44 |
| Heart infiltration | ||||||
| major | 0 | 40 | 0 | 0 | 0 | 33 |
| minor | 5 | 35 | 0 | 29 | 0 | 44 |
| Corneal infiltration | 0 | 26 | 0 | 0 | 0 | 0 |
| ulcer | 0 | 26 | 0 | 0 | 0 | 0 |
| Pancreas infiltration | 5 | 100 | 0 | 88 | 13 | 100 |
| Kidney infiltration | 11 | 37 | 0 | 25 | 0 | 89 |
The values shown represent the percentage of mice displaying a particular lesion.