Figure 1.

The structure of hen-egg lysozyme (HEL) and its antigenic determinants. (a) Schematic representation of the disulphide bonds and the identified T-cell-epitope regions of HEL. Disulphide bridges between the cysteine residues (C) in HEL are indicated with solid lines. An ester linkage between glutamic acid (E) and tryptophan (W) in 35–108CL-HEL is indicated with a dashed line. The dominant epitope HEL_107–116 presented by I-E^d molecules and the subdominant epitope HEL_11–35 presented by I-A^d molecules are indicated by bold lines. The subdominant region was reported to contain two determinants, HEL_11–25 and HEL_20–35.¹⁷,⁴⁹ (b) View of the alpha-carbon backbone of HEL, showing the locations of the disulphide bonds in HEL, the ester bond in 35–108CL-HEL, and the T-cell-determinant regions. This figure was prepared using RasMol version 2·5, with some modifications.