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Insulin release from perfused rat pancreas. (a) compound 2 (10 μM) was administered at t = 20–40 min with 10 mM glucose or with 4 mM glucose. (b) compound 2 (10 μM) was administered at t = 40–55 min, with 7 mM glucose and with 20 pM GLP-1 or without GLP-1. Data are presented as mean ± SD of two to three experiments.
