Table 2.
Allele and carrier frequency analyses of genotyped IFN-γ SNPs
| SNP ID and alleles | Allele frequency, %* |
Carrier† |
||||||
|---|---|---|---|---|---|---|---|---|
| CA | AA | P‡ | OR (95% CI) | P‡ | ||||
| Cohort 1 (IFN-α-treated patients) | ||||||||
| Treatment response | SVR | NR | SVR | NR | ||||
| No. of alleles§ | 180 | 246 | 16 | 126 | ||||
| rs2069705 T/C | T | 66.9 | 33.6 | 81.3 | 54 | 0.398 | 0.81 (0.48–1.35) | 0.407 |
| C | 33.1 | 66.4 | 18.7 | 46 | ||||
| rs2069707 C/G | C | 88.3 | 94.7 | 93.8 | 97.6 | 0.011 | 2.66 (1.27–5.57) | 0.008 |
| G | 11.7 | 5.3 | 6.2 | 2.4 | ||||
| rs2430561 T/A | T | 56.1 | 57 | 62.5 | 80.2 | 0.513 | 1.12 (0.64–1.94) | 0.691 |
| A | 43.9 | 43 | 37.5 | 19.8 | ||||
| rs1861494 A/G | A | 70.8 | 71.1 | 93.8 | 79.8 | 0.729 | 0.89 (0.53–1.50) | 0.663 |
| G | 29.2 | 28.9 | 6.2 | 20.2 | ||||
| rs1861493 T/C | T | 71.3 | 72.1 | 93.8 | 86.5 | 0.963 | 0.92 (0.55–1.56) | 0.771 |
| C | 28.7 | 27.9 | 6.2 | 13.5 | ||||
| rs2069718 C/T | C | 60.1 | 56.1 | 62.5 | 40.3 | 0.174 | 0.72 (0.42–1.24) | 0.23 |
| T | 39.9 | 43.9 | 37.5 | 59.7 | ||||
| rs2069727 A/G | A | 56.7 | 57.8 | 56.3 | 77.8 | 0.434 | 1.16 (0.67–2.01) | 0.591 |
| G | 43.3 | 42.2 | 43.7 | 22.2 | ||||
| rs2069728 G/A | G | 92.1 | 89.3 | 75 | 73.4 | 0.363 | 0.72 (0.37–1.37) | 0.315 |
| A | 7.9 | 10.7 | 25 | 26.6 | ||||
| Cohort 2 (intravenous drug users)¶ | ||||||||
| Viral clearance | C | P | C | P | ||||
| No. of alleles | 16 | 20 | 150 | 302 | ||||
| rs2069707 C/G | C | 87.5 | 100 | 96.7 | 98.3 | 0.086 | 3.51 (0.98–12.49) | 0.044 |
| G | 12.5 | 0 | 3.3 | 1.7 | ||||
P values in boldface are significant.
*Allele frequency is presented as percentage of the column variable: SVR or NR for cohort 1 and spontaneous recovery (C) or persistent infection (P) for cohort 2.
†Carrier refers to carrier of the rarer allele (shown second) according to the National Center for Biotechnology Information dbSNP database.
‡P value is calculated with Cochran Mantel Haenszel (CMH) statistics adjusting for race for comparison between SVR and NR in cohort 1 and C and P in cohort 2.
§In cohort 1, the number of alleles contributing to each SNP analysis depends upon the rate of success in genotyping the particular SNP and varies by no more than ±2 from the number listed.
¶Only the data of SNP rs2069707 are shown for cohort 2. The data for the other SNPs (not significant) are not shown.