Table 3.
Allele, genotype, and carrier frequencies of SNP rs2069707 for IFN-α-treated patients (cohort 1), separately by race
| CA |
AA |
CMH race-adjusted | |||
|---|---|---|---|---|---|
| SVR (%) | NR (%) | SVR (%) | NR (%) | ||
| Allele frequency | |||||
| G | 21 (11.7) | 13 (5.3) | 1 (6.2) | 3 (2.4) | |
| C | 159 (88.3) | 233 (94.7) | 15 (93.8) | 123 (97.6) | |
| P | 0.016 | 0.384 | 0.011 | ||
| Genotype frequency | |||||
| GG | 1 (1.1) | 1 (0.8) | 0 | 0 | |
| CG | 19 (21.1) | 11 (8.9) | 1 (12.5) | 3 (4.8) | |
| CC | 70 (77.8) | 111 (90.3) | 7 (87.5) | 60 (95.2) | |
| P | 0.04 | NC | 0.028 | ||
| G carrier frequency | |||||
| GG or CG | 20 (22.2) | 12 (9.7) | 1 (12.5) | 3 (4.8) | |
| CC | 70 (77.8) | 111 (90.3) | 7 (87.5) | 60 (95.2) | |
| P | 0.012 | 0.387 | 0.008 | ||
| OR (95% CI) | 2.64 (1.22–5.74) | 2.86 (0.26–31.33) | 2.66 (1.27–5.57) | ||
P values in boldface are significant. CMH, Cochran Mantel Haenszel statistics; NC, not calculated due to zero observation for GG genotype.