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. 2007 Jan 10;104(3):991–996. doi: 10.1073/pnas.0610270104

Fig. 1.

Fig. 1.

Incidence of apoptosis and expression of collagen VI in muscle biopsies from a healthy donor and UCMD patients. (A) Biopsies from a healthy donor (CTRL) and five UCMD patients (P1–P5) were scored for the presence of apoptotic nuclei with the TUNEL reaction. For patient 4, columns 1 and 2 refer to biopsies taken at 4 and 9 years of age, respectively. ∗, P < 0.01 for each patient vs. healthy donor. (B) Muscle biopsies from a healthy donor (CTRL) and five UCMD patients (P1–P5) were studied by immunofluorescence for collagen VI. (Scale bar, 20 μm.) (C) Muscle biopsies from a healthy donor (CTRL) and three UCMD patients (P2–P4) were studied by immunofluorescence for collagen VI (COLVI, green fluorescence) (Top) and perlecan (red fluorescence) (Middle), and a merge is shown in Bottom. Arrowheads mark examples of a lack of collagen VI staining at the basal lamina. (Scale bars, 20 μm.)