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Model for the regulation of UV-induced apoptosis in the Drosophila retina. JNK activation results in Foxo- and Fos-dependent transcriptional upregulation of hid. Hid inhibits IAP and induces caspase-dependent apoptosis. Induction of hid can be blocked by InR or EGFR-initiated survival signals that inhibit Foxo activity. The relative balance between stress (JNK) and survival (RTK) signaling determines the cellular response to UV-induced DNA damage.
