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Model for CTIP2-mediated establishment of heterochromatin environment to HIV-1 gene promoter and viral silencing. CTIP2 first recruits HDAC1 and HDAC2 enzymes to deacetylate H3 histones located at the viral promoter and particularly Nuc-1 H3 histones. After H3 deacetylation, CTIP2 recruits SUV39H1 to methylate Nuc-1 histone H3 lysine 9. This last H3 modification allows HP1 binding and polymerization, heterochromatin formation and HIV-1 silencing.
