Figure 1.
CaV1.3 knockout mice are neurologically normal. (A) Mice were placed on the accelerating rotarod for a maximum of 300 sec once a day for 5 d and the latency to fall was recorded for CaV1.3 knockout mice and wild-type littermates. The latency to fall for knockout mice was not significantly different from wild-type animals. (B,C) Exploratory behavior as measured in the open field was similar in CaV1.3 knockout mice and wild-type littermates both in the overall distance traveled (B) and in the ratio between the distance traveled in the center divided by the total distance traveled (C). (D) Average body weight was not significantly different between wild-type mice and the CaV1.3 knockout mice. All data are presented as mean ±SEM.