Figure 3.
CaV1.3 knockout mice exhibit normal short- and long-term extinction. (A) CaV1.3 knockout freeze to a similar degree as their wild-type littermates at the beginning of testing on day 3, overcoming the impairment exhibited on day 2. *P < 0.05 for post hoc comparisons between genotypes. (B) Short-term extinction in CaV1.3 knockout mice was not significantly different from wild-type mice, with both groups freezing significantly less by the end of the 30-min exposure to the context (10-min bins). (C) Twenty-four hours after the extinction training, mice were re-exposed to the same context for 5 min to measure long-term extinction. There was no difference between CaV1.3 knockout and wild-type mice in levels of freezing (P > 0.1) after extinction. However, both groups (knockouts and wild types) showed significant reductions in freezing when compared with mice of the same genotype that had not been re-exposed to the context (P < 0.05 and P < 0.005 for wild-type and knockouts vs. retention control group). All data are presented as mean ±SEM.