Figure 4.
CaV1.3 knockout mice are not impaired in the Morris water maze. (A) Mice were trained for two trials a day for 6 d. The time to reach the hidden platform (escape latency) was not significantly different for CaV1.3 knockout mice when compared with wild-type littermate control mice. (B) A 60-sec probe trial completed 24 h after the last training trail (trial 12; day 6) reveals that both CaV1.3 knockout and wild-type mice spend a significant amount of time during the trial searching in the quadrant where the platform was previously located (TQ; training quadrant), but there was no significant difference between the genotypes. The dashed line (25%) represents random or “chance” performance. (AR) Adjacent right; (AL) adjacent left; (OP) opposite. (C) Average escape latencies for CaV1.3 knockout mice recorded during the visible platform version of the Morris water maze were not significantly different when compared with wild-type littermate controls. All data are presented as mean ±SEM.