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Schematic diagram of CREB-binding protein (CBP) showing different functional domains. (A) The endogenous allele of CBP generates a protein product with multiple domains, including several protein–protein interaction motifs as well as the histone acetyltransferase domain. (B) The CBPKIX allele generates a protein product carrying three point mutations in the CREB-binding domain (KIX). These mutations block the interaction between phosphorylated CREB and CBP.
