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. 2006 Nov-Dec;13(6):690–698. doi: 10.1101/lm.390506

Figure 1.

Figure 1.

Sound sequence discrimination test. (A) Experimental setup for sound sequence discrimination test. Rats were trained to discriminate between sound sequences in a Skinner box. Licking a spout during sound presentation of a particular sequence was rewarded with water containing 0.1% saccharine. (B) An example of rewarded (S+) and unrewarded (S−) sound sequence. A PT and an AM tone with a sawtooth wave were sequentially presented five times at 2-sec intervals. In each trial, either S+ or S− was randomly presented. (C) Schedule of discrimination test. After procedural training for rats to respond to the sound stimuli with licking, 720 trials were repeated at 1-min intervals during a test session of 12 h. The test session was conducted on four consecutive days. (D) Percentage of trials with licking to sound sequence presentation was calculated separately for S+ and S− every 2 h during the session (mean ± SEM). (E) Test performance was estimated as the difference in the percentage of trials with licking between S+ and S−. The results for the first 6 h of the session (mean ± SEM) are shown.