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. 2006 Nov-Dec;13(6):690–698. doi: 10.1101/lm.390506

Figure 4.

Figure 4.

Effects of 6-OHDA lesions in the NAc on sound discrimination learning. (A) Bilateral 6-OHDA lesions in the NAc attenuated sound sequence discrimination learning (*P < 0.05). (B) Total number of trials with licking during the test session was not attenuated by the 6-OHDA lesions. (C) 6-OHDA lesions attenuated discrimination between the PT and AM sound sequence components (*P < 0.05). (D) 6-OHDA lesions attenuated discrimination learning between AMs with modulation depths of 70% and 30% (*P < 0.05). (E) Immunostaining of tyrosine hydroxylase in the mPFC of a control rat (left) and a rat injected with 6-OHDA to the mPFC (right). (F,G) 6-OHDA lesions in the mPFC had no significant effect on sound sequence discrimination learning (F) or licking behavior (G).