Table 1.
General scheme of the study
| Phase A | Phase B | ||||
| Randomisation | |||||
| by cages |  |  | |||
| within cages by treatments | - |  | |||
| Blinding | |||||
| Treatment administration | - |  | |||
| Edema measurement |  |  | |||
| Inflammation model | CA | BL | CA | ||
| Homeopathic remedies | |||||
| dilution | n. of animals studied | ||||
| Arnica | D4 | 71 | O/I | O/I | - | 
| Apis | D4 | 90 | O/I | O/I | O | 
| Apis | D30 | 18 | - | - | O | 
| Atropa | D4 | 72 | O/I | O/I | - | 
| Hamamelis | D4 | 72 | O/I | O/I | - | 
| Lachesis | D6 | 86 | O/I | O/I | O | 
| Lachesis | D30 | 18 | - | - | O | 
| Phosphorus | D6 | 90 | O/I | O/I | O | 
| Phosphorus | D30 | 18 | - | - | O | 
| Reference treatments | |||||
| Placebo: | |||||
| Physiological solution | 86 | O/I | O/I | O | |
| Active comparator: | |||||
| Indomethacin | 88 | I/I | I/I | I | |
O = oral administration
I = administration through injection
CA = carrageenan induced edema
BL = autologous blood induced edema
Each treatment group has been tested through 3 replications. In each replication 6 rats were studied. In experiment A 11 rats were excluded from the analyses because of problems with edema induction.