Table 4.
Experiment A: Blood edema and oral administration
| Drug | Paw volume increase over time (ml ± SD) and effect (% of negative control) | |||||||
| 1 hr | 2 hr | 3 hr | 5 hr | |||||
| Saline | 0.60 ± 0.12 | 0.63 ± 0.11 | 0.55 ± 0.15 | 0.36 ± 0.13 | ||||
| Arnica D4 | 0.58 ± 0.08 | -5 | 0.61 ± 0.08 | -4 | 0.52 ± 0.11 | -5 | 0.38 ± 0.11 | 7 |
| Apis D4 | 0.55 ± 0.08 | -8 | 0.66 ± 0.08 | 4 | 0.55 ± 0.15 | 0 | 0.35 ± 0.13 | -1 |
| Atropa D4 | 0.57 ± 0.08 | -6 | 0.63 ± 0.11 | -1 | 0.54 ± 0.15 | -2 | 0.33 ± 0.11 | -7 |
| Hamamelis D4 | 0.57 ± 0.07 | -6 | 0.62 ± 0.08 | -2 | 0.50 ± 0.13 | -9 | 0.31 ± 0.10 | -12 |
| Lachesis D6 | 0.55 ± 0.14 | -10 | 0.63 ± 0.11 | -1 | 0.50 ± 0.15 | -9 | 0.31 ± 0.12 | -13 |
| Phosphorus D6 | 0.54 ± 0.08 | -11 | 0.62 ± 0.09 | -2 | 0.53 ± 0.12 | -4 | 0.33 ± 0.09 | -7 |
| Indomethacin i.m. | 0.51 ± 0.10 | -16 | 0.46 ± 0.10 | -27 | 0.36 ± 0.12 | -35 | 0.22 ± 0.10 | -39 |
ANOVA results. Treatment: F(7,135) = 4.40, p = 0.0002; Time: F(3,405) = 535.25, p < 0.0001; Treatment × time (F(21,405) = 2.66, p = 0.0004.
Bold characters denote significant comparisons (by Student t test) vs. Saline group corresponding for time since edema induction.