Table 6.
Experiment B: Carageenan edema and oral administration
| Drug | Paw volume increase over time (ml ± SD) and effect (% of negative control) | |||||||
| 1 hr | 3 hr | 5 hr | 7 hr | |||||
| Saline | 0.39 ± 0.17 | 0.77 ± 0.16 | 0.63 ± 0.18 | 0.54 ± 0.16 | ||||
| Apis D4 | 0.37 ± 0.11 | -7 | 0.81 ± 0.11 | +6 | 0.70 ± 0.20 | +12 | 0.60 ± 0.15 | +11 |
| Apis D30 | 0.43 ± 0.11 | +8 | 0.82 ± 0.11 | +7 | 0.73 ± 0.17 | +16 | 0.59 ± 0.13 | +10 |
| Lachesis D6 | 0.40 ± 0.12 | +1 | 0.79 ± 0.19 | +3 | 0.71 ± 0.18 | +14 | 0.58 ± 0.17 | +7 |
| Lachesis D30 | 0.40 ± 0.17 | +2 | 0.79 ± 0.19 | +3 | 0.75 ± 0.19 | +19 | 0.59 ± 0.21 | +10 |
| Phosphorus D6 | 0.40 ± 0.15 | +1 | 0.80 ± 0.18 | +4 | 0.70 ± 0.16 | +11 | 0.59 ± 0.20 | +10 |
| Phosphorus D30 | 0.41 ± 0.16 | +3 | 0.85 ± 0.23 | +11 | 0.72 ± 0.21 | +14 | 0.59 ± 0.18 | +10 |
| Indomethacin i.m. | 0.30 ± 0.14 | -24 | 0.48 ± 0.15 | -38 | 0.52 ± 0.10 | -18 | 0.43 ± 0.10 | -20 |
ANOVA results for measurements from 1 to 7 hrs since edema induction. Treatment: F(7,14) = 4.23, p = 0.0105; Time: (F(3,6) = 26.91, p = 0.0007; Treatment × time (different profiles over time between treatments): F(21,42) = 2.07, p = 0.1010; Replication × time (different profiles over time between replications): F(6,45) = 8.61, p < 0.0001; Replication × treatment × time (different profiles over time between replications and treatments): F(42,315) = 1.65, p = 0.0110.
Bold characters denote significant comparisons (by Student t test) vs. Saline group corresponding for time since edema induction.