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. Author manuscript; available in PMC: 2007 Jan 29.
Published in final edited form as: J Gerontol A Biol Sci Med Sci. 2006 Oct;61(10):1075–1081. doi: 10.1093/gerona/61.10.1075

Table 5.

Adverse Events During DPP by Age and Treatment Groups

Placebo
 Metformin
 Lifestyle
Events 25–44 45–59 60–85 25–44 45–59 60–85 25–44 45–59 60–85
Gastrointestinal (No. of events/100 person-years)*  32.4  30.8 27.8 82.2 77.5 72.2  13.1  14.2  9.7
Musculoskeletal (No. of events/100 person-years)†  16.1  21.9 26.7 13.3 21.4 26.1  19.9  25.4 28
Hospitalization
   One or more admissions (% of participants)  11.1  16.9 21.9 10.1 16.8 22.4  15.4  13.3 20.6
   Rate (No. of admissions/100 person-years)   6.3   7.9 10.6  4.4  8.8 13.3   7.5   6.4 12.3
   Median stay, days   3   3  4  3  3  4   3   3  3
Deaths (No./100 person-years)   0   0  0.86  0.11  0.13  0.48   0.1   0  0.31

Notes: DPP = Diabetes Prevention Program.

*

Gastrointestinal symptoms included diarrhea, flatulence, nausea, and vomiting.

†

Most participants with musculoskeletal symptoms had myalgia, arthritis, or arthralgia.